High Sensitivity Troponin (hsTnT) : Result Interpretation Matrix* 1st hsTnT on presentation High Risk of Myocardial Ischaemia Low Risk of Myocardial Ischaemia Clinical Assessment Result > 14 ? Result > 100 ? > 6 hrs of symptoms? 2 ndhsTnT (taken at >6 hours post symptom onset AND >3 hours from 1st test) 1st or 2 Result > 14 and > 50% change ? YES YES NO NO YES NO
3 Dec 2020 between baseline biomarkers ↔️ CV ☠️ /HF with/out iSGLT2 in #DECLARE ‐TIMI 58 T2DM & higher NT‐proBNP/hsTnT are at
This is seemingly contradicted by Reichlin et al., who claimed that a simple algorithm incorporating hsTnT baseline values and absolute changes within the first hour allowed a safe rule-out and an accurate rule-in of AMI in 77% of randomly selected patients with acute chest pain [65]. However, the relationship between hsTnT and renal outcomes remained strong (p < 0.001) even after adjusting for baseline eGFR. hsTnT is a marker of myocardial injury and micronecrosis, it is therefore possible that cardiac vascular disease, reflected by slightly raised hsTnT levels, could be paralleled by vascular disease in other organs, including the kidneys . Results: The median baseline NT-proBNP and hsTnT levels were 75 pg/mL (IQR 35-165) and 10.2 pg/mL (IQR 6.9-15.5), respectively.
Elevated hsTnT levels are associated with death and decreased right ventricle function in patients with PAH . hsTnT baseline values were >14 ng/L and thus pathologic-ally elevated in 4 patients. Elevated hsTnT levels are associ-ated with death and decreased right ventricle function in patients with PAH [14]. We found a close relationship between hsTnT levels and NT-proBNP at baseline (r=0.7, p<0.01) as well as 5 hours after maximal exercise (r=0.667, 2020-11-01 · The length of hospitalisation was longer in patients with baseline HsTnT ≥50 ng/L compared to patients who had baseline HsTnT ≤14 ng/L, which may reflect the number of comorbidities. These were probably major contributors to the high re-admission rates we report, with approximately one-quarter of patients being re-admitted by 30 days, and two out of three readmitted by 1 year. Objective: To determine if a baseline hsTnT value ≤99th percentile upper reference limit (0.014 ug/L (“low hsTnT”)) identifies patients at low risk for adverse events. Methods: RELAX-AHF randomized AHF patients who were dyspneic, congested, with a SBP ≥125mmHg, moderate renal impairment, NT-proBNP ≥1600ng/L, and enrolled within 16 hours of presentation to serelaxin vs.
2021-03-22 · High sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship 2018-10-09 · The changes in hsTnT levels from baseline to 1 year were larger, but not significantly so, among those with more frequent hypoglycemia: median of 0.6 ng/l (IQR: –1.3 to +2.7 ng/l) in those without hypoglycemia, 1.0 ng/l (IQR: –1.3 to +3.3 ng/l) in those with episodes less than weekly, and 1.0 ng/l (IQR: –1.0 to +3.4 ng/l) among those with episodes greater than or equal to weekly (p = 0.075).
A rule-out strategy based on a single hsTnT at presentation and using lower cutoffs has been proposed by others. 26,27 However, in our study, a single hsTnT level of 19 ng/L or less is probably inadequate because it provided an AMI NPV of only 98.2% at baseline presentation.
Objective: To determine if a baseline hsTnT value ≤99th percentile upper reference limit (0.014 ug/L (“low hsTnT”)) identifies patients at low risk for adverse events. Methods: RELAX-AHF randomized AHF patients who were dyspneic, congested, with a SBP ≥125mmHg, moderate renal impairment, NT-proBNP ≥1600ng/L, and enrolled within 16 hours of presentation to serelaxin vs. placebo. Whereas hsTnT levels were <14 ng/L (limit of quantification) in these control subjects (3.34 ng/L, 3.96 ng/L and 5.97 ng/L), hsTnT baseline values were >14 ng/L and thus pathologically elevated in 4 patients.
High Sensitivity Troponin (hsTnT) : Result Interpretation Matrix* 1st hsTnT on presentation High Risk of Myocardial Ischaemia Low Risk of Myocardial Ischaemia Clinical Assessment Result > 14 ? Result > 100 ? > 6 hrs of symptoms? 2 ndhsTnT (taken at >6 hours post symptom onset AND >3 hours from 1st test) 1st or 2 Result > 14 and > 50% change ? YES YES NO NO YES NO
hsTnT is a marker of myocardial injury and micronecrosis, it is therefore possible that cardiac vascular disease, reflected by slightly raised hsTnT levels, could be paralleled by vascular disease in other organs, including the kidneys .
At baseline, hsTnT was higher in patients with diabetic ne-phropathy than in patients with normoalbuminuria (median [interquartile range]: 8.9 [4.1–17.2] vs. 3.1 [1.1–6.0
Combination of baseline hsTnT levels with the sPESI allowed a more reliable identification of patients with a favorable long-term (6-month) prognosis (Figure 3, bottom, P<0.001; and Figure 4). Only 1 patient (0.8 [0.0–4.3]%) with a sPESI of 0 and hsTnT <14 pg/mL died within the 6-month follow-up period. This is seemingly contradicted by Reichlin et al., who claimed that a simple algorithm incorporating hsTnT baseline values and absolute changes within the first hour allowed a safe rule-out and an accurate rule-in of AMI in 77% of randomly selected patients with acute chest pain [65].
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METHODS AND RESULTS: In the British Regional Heart Study, 3852 men aged 60-79years without baseline HF (3165 without baseline chronic heart disease) were followed for a median of 12.6years, during which 295 incident cases of HF occurred (7.7%).
The median baseline NT-proBNP and hsTnT levels were 75 pg/mL (IQR 35-165) and 10.2 pg/mL (IQR 6.9-15.5), respectively. Elevated baseline baseline hsTnT was associated with NIHSS, creatinine, ST segment depression and inverted T waves, but not with stroke location or size.
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High Sensitive Troponin T (hsTnT) and Copeptin as Prognostic Parameters in Usual baseline characteristics are taken as well as usual blood results (hb,
Postoperative hsTnT elevation was present in 53.2% of the population. An association between MAP quartile and postoperative peak hsTnT was predomi-nantly observed in the lowest quartile (P<0.001): median hsTnT 17.6 (10.3e37.3), 14.9 (9.4e24.6), 13.8 (9.1e22.5 Similarly, for hsTnT, we remeasured any baseline hsTnT measure with a value <5 ng/L by using the newer Roche E601 instrument, which had a limit of blank of 2.5 ng/L and limit of detection of <3 ng/L. With the E601 instrument, at a concentration of 13.5 ng/L, the CV was 1.9%; at 4,831 ng/L, the CV was 0.8%. 2019-07-09 · For pragmatic reasons, baseline data including prevalence of comorbidities such as CKD and CHF, which may influence hsTnT values, was not collected.